A Comprehensive Review on the Techniques for Extraction of Bioactive Compounds from Medicinal Cannabis

Molecules

Amrita Basu¹  Deep Jyoti Bhuyan²  Muhammad A. Alsherbiny²  Quan V. Vuong³  Hebah Muhsien Sabiah AL Ubeed⁴ 

[1] Complex Carbohydrate Research Centre, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA;NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia;School of Environmental and Life Sciences, College of Engineering, Science, and Environment, The University of Newcastle, 10 Chittaway Road, Ourimbah, NSW 2258, Australia;School of Science, College of Sciences, Engineering, Computing Technologies and Health and Medical Sciences, RMIT University, Bundoora, Melbourne, VIC 3083, Australia;

关键词: Cannabis;    medicinal cannabis;    cannabinoids;    extraction techniques;   

DOI  :  10.3390/molecules27030604

来源: DOAJ

【 摘 要 】

Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of Cannabis research. The evaluation of the current extraction methods implemented in the Cannabis industry and scientific literature to produce consistent, reliable, and potent medicinal Cannabis extracts is prudent. Furthermore, these processes must be subjected to higher levels of scientific stringency, as Cannabis has been increasingly used for various ailments, and the Cannabis industry is receiving acceptance in different countries. We comprehensively analysed the current literature and drew a critical summary of the extraction methods implemented thus far to recover bioactive compounds from medicinal Cannabis. Moreover, this review outlines the major bioactive compounds in Cannabis, discusses critical factors affecting extraction yields, and proposes future considerations for the effective extraction of bioactive compounds from Cannabis. Overall, research on medicinal marijuana is limited, with most reports on the industrial hemp variety of Cannabis or pure isolates. We also propose the development of sustainable Cannabis extraction methods through the implementation of mathematical prediction models in future studies.

【 授权许可】

Unknown