Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases

International Journal of Molecular Sciences

Elena V. Schmalhausen¹  Lidia P. Kurochkina¹  Vladimir I. Muronetz¹  Kseniya V. Barinova¹  Sofia S. Kudryavtseva²  Evgeniia V. Leisi³ 

[1] Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia;Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia;Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia;

关键词: alpha-synuclein;    amyloid proteins;    chaperones;    chaperonins;    microbiota;    misfolded proteins;   

DOI  :  10.3390/ijms23052747

来源: DOAJ

【 摘 要 】

The review highlights various aspects of the influence of chaperones on amyloid proteins associated with the development of neurodegenerative diseases and includes studies conducted in our laboratory. Different sections of the article are devoted to the role of chaperones in the pathological transformation of alpha-synuclein and the prion protein. Information about the interaction of the chaperonins GroE and TRiC as well as polymer-based artificial chaperones with amyloidogenic proteins is summarized. Particular attention is paid to the effect of blocking chaperones by misfolded and amyloidogenic proteins. It was noted that the accumulation of functionally inactive chaperones blocked by misfolded proteins might cause the formation of amyloid aggregates and prevent the disassembly of fibrillar structures. Moreover, the blocking of chaperones by various forms of amyloid proteins might lead to pathological changes in the vital activity of cells due to the impaired folding of newly synthesized proteins and their subsequent processing. The final section of the article discusses both the little data on the role of gut microbiota in the propagation of synucleinopathies and prion diseases and the possible involvement of the bacterial chaperone GroE in these processes.

【 授权许可】

Unknown