Pericytes: Multitasking Cells in the Regeneration of Injured, Diseased, and Aged Skeletal Muscle

Frontiers in Aging Neuroscience

Osvaldo eDelbono¹  Alexander eBirbrair¹  Akiva eMintz¹  Zhong-Min eWang¹  Maria Laura Messi¹  Tan eZhang¹ 

[1] Wake Forest School of Medicine;

关键词: Aging;    Pericytes;    Regeneration;    Stem Cells;    skeletal muscle;    Angiogenesis;   

DOI  :  10.3389/fnagi.2014.00245

来源: DOAJ

【 摘 要 】

Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes’ influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.

【 授权许可】

Unknown