Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity

Molecules

Seong-Jin Choi¹  Jaehyuk Choi²  Kwang-Hyun Baek²  Awdhesh Kumar Mishra² 

[1] Department of Biotechnology, Daegu Catholic University, Gyeongsan 38430, Korea;Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea;

关键词: aa-tRNAsynthetase;    cyclodipeptides;    cyclodipeptide synthase;    non-ribosomal peptide synthetase;    tailoring enzyme;   

DOI  :  10.3390/molecules22101796

来源: DOAJ

【 摘 要 】

Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmacological activities. CDP synthases (CDPSs) and non-ribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of the CDP core structure, which is further modified by tailoring enzymes often associated with CDP biosynthetic gene clusters. In this review, we provide a comprehensive summary of CDP biosynthetic pathways and modifying enzymes. We also discuss the biological properties of some known CDPs and their possible applications in metabolic engineering.

【 授权许可】

Unknown