Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

Plants

Ana Silvia Gutierrez-Roman¹  Manasés González-Cortazar¹  Alejandro Zamilpa¹  Ma Dolores Perez-García¹  Alejandro Bugarin²  Ricardo López-Rodríguez³  Carlos Ernesto Lobato-García³  Ever A. Ble-González³  Abraham Gómez-Rivera³  Patricia Álvarez-Fitz⁴ 

[1] Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico;Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965, USA;División Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa Km. 0.5, Cunduacán 86690, Tabasco, Mexico;Laboratorio de Toxicología, Cátedra CONACyT-Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas s/n. Col. La Haciendita, Chilpancingo 39070, Guerrero, Mexico;

关键词: Acalypha arvensis;    ellagitannin;    corilagin;    Staphylococcus aureus;    flavonoids;    antibacterial;   

DOI  :  10.3390/plants11030300

来源: DOAJ

【 摘 要 】

There is a significant need to gain access to new and better antibacterial agents. Acalypha arvensis, a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of Acalypha arvensis. Specifically, three extracts were assessed (n-hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin (1) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid (2), rutin (3), quercetin-3-O-glucoside (4), caffeic acid (5), among others (6–8). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria.

【 授权许可】

Unknown