Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice

Journal of Mind and Medical Sciences

Rucsandra E. Dănciulescu Miulescu¹  Carmen Limban²  Diana C. Nuță²  Cornel Chiriță³  Simona Negreș³  Cristina E. Zbârcea³  Cristina D. Marineci³  Emil Ștefănescu³  Horațiu Mireșan⁴ 

[1] Carol Davila University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Endocrinology;Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry;Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, Bucharest, Romania;Ovidius University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Toxicology, Constanța, Romania;

关键词: doxepin;    selegiline;    antidepressant;    pharmacological research;   

DOI  :  10.22543/7674.62.P261270

来源: DOAJ

【 摘 要 】

The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a synergism of action between a classical tricyclic antidepressant that inhibits noradrenalin and serotonin reuptake (doxepin), and a modern antidepressant that inhibits type-B monoamine oxidase (selegiline). We measured the antidepressant effect using the forced swimming test and the tail suspension test. We determined motor activity using the Activity Cage test. Our results have shown that the antidepressant effect intensifies significantly in the animals treated with both antidepressants simultaneously compared to those treated only with doxepin. Furthermore, we observed that selegiline decreases the sedative effect of doxepin in the Activity Cage test.

【 授权许可】

Unknown