Human hippocampal CA3 damage disrupts both recent and remote episodic memories

eLife

Paul Maddison¹  Trevor T-J Chong²  Sarosh R Irani³  Christopher Kennard⁴  Michael R Johnson⁵  Masud Husain⁶  Anne M Aimola Davies⁷  Penny A Gowland⁸  Clive R Rosenthal⁹  Thomas D Miller^1,10  Saiju Jacob^1,10  Tammy WC Ng^1,10 

[1] Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom;Department of Neurology, Royal Free Hospital, London, United Kingdom;Research School of Psychology, Australian National University, Canberra, Australia;Department of Anaesthestics, Royal Free Hospital, London, United Kingdom;Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom;Division of Brain Sciences, Imperial College London, London, United Kingdom;Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, Australia;Neurology Department, Queen Elizabeth Neuroscience Centre, University Hospitals of Birmingham, Birmingham, United Kingdom;Neurology Department, Queen’s Medical Centre, Nottingham, United Kingdom;Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;

关键词: hippocampal subfields;    retrograde amnesia;    episodic memory;    cornu ammonis;    default network;    LGI1-antibody limbic encephalitis;   

DOI  :  10.7554/eLife.41836

来源: DOAJ

【 摘 要 】

Neocortical-hippocampal interactions support new episodic (event) memories, but there is conflicting evidence about the dependence of remote episodic memories on the hippocampus. In line with systems consolidation and computational theories of episodic memory, evidence from model organisms suggests that the cornu ammonis 3 (CA3) hippocampal subfield supports recent, but not remote, episodic retrieval. In this study, we demonstrated that recent and remote memories were susceptible to a loss of episodic detail in human participants with focal bilateral damage to CA3. Graph theoretic analyses of 7.0-Tesla resting-state fMRI data revealed that CA3 damage disrupted functional integration across the medial temporal lobe (MTL) subsystem of the default network. The loss of functional integration in MTL subsystem regions was predictive of autobiographical episodic retrieval performance. We conclude that human CA3 is necessary for the retrieval of episodic memories long after their initial acquisition and functional integration of the default network is important for autobiographical episodic memory performance.

【 授权许可】

Unknown