Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Frontiers in Pharmacology

Jing Lei¹  Shi Wu¹  Yaobin Pang¹  Yejing Yao¹  Yingjie He¹  Qing Nian¹  Jing Guo¹  Jinhao Zeng³ 

[1] Dermatological Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Geriatric Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;

关键词: vitiligo;    oxidative stress;    natural product;    melanocytes;    flavonoids;    phenols;   

DOI  :  10.3389/fphar.2021.685116

来源: DOAJ

【 摘 要 】

Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.

【 授权许可】

Unknown