Association of T Stage and Serum CEA Levels in Determining Survival of Rectal Cancer

Frontiers in Medicine

Shengwen Wu¹  Wenlong Gu² 

[1] Department of General Surgery, The Affiliated Jianhu Hospital of Nantong University, Jianhu People's Hospital, Jianhu, China;Department of Medical Oncology, The Affiliated Jianhu Hospital of Nantong University, Jianhu People's Hospital, Jianhu, China;

关键词: T stage;    carcinoembryonic antigen;    rectal cancer;    survival;    SEER;   

DOI  :  10.3389/fmed.2019.00270

来源: DOAJ

【 摘 要 】

Purpose: To investigate the association of T stage and serum carcinoembryonic antigen (CEA) levels in determining oncologic outcomes of rectal cancer.Methods: Patients diagnosed with stage I–II rectal cancer patients were identified from the Surveillance, Epidemiology, and End Results database.Results: In stage T1N0M0 disease, elevated level of serum CEA (C1) was associated with 227.6% increased risk of mortality compared to normal level of serum CEA (C0; hazard ratio = 3.276, 95% confidence interval = 2.781–3.858, P < 0.001).Conclusions: Stage T1N0M0 rectal cancer, when involved in preoperative serum CEA elevation, may be a surrogate of biologically aggressive disease and correlate with unfavorable oncologic outcomes. Moreover, this subgroup of rectal cancer deserves more clinical attention of oncologists.

【 授权许可】

Unknown