Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy

Advanced Science

Qiangbing Guo¹  Xiaoxu Zhao¹  Stephen J. Pennycook¹  Qiuhong Zhang²  Qian Chen²  Hangrong Chen² 

[1] Department of Materials Science and Engineering National University of Singapore Singapore 117575 Singapore;State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China;

关键词: Fenton agent;    FePS3 nanosheets;    NIR‐II biowindow;    photothermal agents;    reactive oxygen species;   

DOI  :  10.1002/advs.201902576

来源: DOAJ

【 摘 要 】

Abstract Photothermal therapy (PTT) has emerged as a promising cancer therapeutic modality with high therapeutic specificity, however, its therapeutic effectiveness is limited by available high‐efficiency photothermal agents (PTAs), especially in the second near‐infrared (NIR‐II) biowindow. Here, based on facile liquid‐exfoliated FePS3 nanosheets, a highly efficient NIR‐II PTA with its photothermal conversion efficiency of up to 43.3% is demonstrated, which is among the highest reported levels in typical PTAs. More importantly, such Fe‐based 2D nanosheets also show superior Fenton catalytic activity facilitated by their ultrahigh specific surface area, simultaneously enabling cancer chemodynamic therapy (CDT). Impressively, the efficiency of CDT could be further remarkably enhanced by its photothermal effect, leading to cancer synergistic PTT/CDT. Both in vitro and in vivo studies reveal a highly efficient tumor ablation under NIR‐II light irradiation. This work provides a paradigm for cancer CDT and PTT in the NIR‐II biowindow via a single 2D nanoplatform with desired therapeutic effect. Furthermore, with additional possibilities for magnetic resonance imaging, photoacoustic tomography, as well as drug loading, this Fe‐based 2D material could potentially serve as a 2D “all‐in‐one” theranostic nanoplatform.

【 授权许可】

Unknown