When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease

EMBO Molecular Medicine

Akim Strohmeyer¹  Martin Klingenspor¹  Mohammed Hankir²  Magdalena Wit³  Grzegorz Sumara³  Jonathan Trujillo‐Viera⁴ 

[1] Chair for Molecular Nutritional Medicine Technical University of Munich TUM School of Life Sciences Weihenstephan Freising Germany;Department of General, Visceral, Transplant, Vascular and Pediatric Surgery University Hospital Wuerzburg Wuerzburg Germany;Nencki Institute of Experimental Biology Polish Academy of Sciences Warszawa Poland;Rudolf‐Virchow‐Zentrum Center for Integrative and Translational Bioimaging University of Würzburg Würzburg Germany;

关键词: enterocyte;    fat absorption;    intestine;    metabolic diseases;    triglycerides;   

DOI  :  10.15252/emmm.202114742

来源: DOAJ

【 摘 要 】

Abstract The regular overconsumption of energy‐dense foods (rich in lipids and sugars) results in elevated intestinal nutrient absorption and consequently excessive accumulation of lipids in the liver, adipose tissue, skeletal muscles, and other organs. This can eventually lead to obesity and obesity‐associated diseases such as type 2 diabetes (T2D), non‐alcoholic fatty liver disease (NAFLD), cardiovascular disease, and certain types of cancer, as well as aggravate inflammatory bowel disease (IBD). Therefore, targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential. In this review, we discuss the molecular and cellular mechanisms controlling intestinal lipid handling, their relevance to the development of metabolic diseases, and emerging therapeutic strategies.

【 授权许可】

Unknown