Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Journal of Pharmacological Sciences

Katsunori Iwasaki¹  Kaori Kubota¹  Haruna Kuwano¹  Masaki Nagao¹  Hikari Iba¹  Nobuaki Egashira¹  Rikako Kawanaka¹  Shutaro Katsurabayashi¹  Takuya Watanabe¹  Hiroshi Moriyama¹ 

[1] Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan;

关键词: Kamishoyosan;    Conditioned fear stress;    Ovariectomized rats;   

DOI  :  10.1016/j.jphs.2016.07.007

来源: DOAJ

【 摘 要 】

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

【 授权许可】

Unknown