Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder

Brain Sciences

Jennifer Barnett¹  Katja Häkkinen²  Markku Lähteenvuo²  Jari Tiihonen²  Atiqul Haq Mazumder³  Martta Kerkelä³  Tuomas Jukuri³  Juha Veijola³  Tiina Paunio⁴  Asko Wegelius⁴  Nina Lindberg⁴  Erkki Tapio Isometsä⁴  Tuula Kieseppä⁴  Jouko Lönnqvist⁵  Solja Niemelä⁶  Jarmo Hietala⁶  Olli Kampman⁷  Seppo Juhani Vainio⁸  Aarno Palotie⁹  Jussi Niemi-Pynttäri⁹  Willehard Haaki⁹  Ari Ahola-Olli⁹  Risto Kajanne⁹  Kaisla Lahdensuo⁹  Kimmo Suokas⁹  Teemu Männynsalo⁹  Minna Torniainen-Holm^1,10  Erik Cederlöf^1,10  Jaana Suvisaari^1,10 

[1] Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK;Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland;Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland;Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland;Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland;Department of Psychiatry, University of Turku, 20014 Turku, Finland;Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland;Infotech Oulu, University of Oulu, 90014 Oulu, Finland;Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland;Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland;

关键词: cognition;    visual memory;    reaction time;    alcohol;    bipolar disorder;   

DOI  :  10.3390/brainsci11091154

来源: DOAJ

【 摘 要 】

The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase.

【 授权许可】

Unknown