Gut Microbiota and Bipolar Disorder: An Overview on a Novel Biomarker for Diagnosis and Treatment

International Journal of Molecular Sciences

Yong-Ku Kim¹  Alessandro Gentile²  Massimo Di Giannantonio³  Lorenza Lucidi³  Franca Ceci³  Francesco Di Carlo³  Mauro Pettorruso³  Federica Vellante³  Giovanni Martinotti³  MariaChiara Santovito³  Ilenia Di Muzio³  Silvia Fraticelli³  Michele Fornaro⁴  Antonio Ventriglio⁵  Domenico De Berardis⁶  Carmine Tomasetti⁷  Alessandro Valchera⁸ 

[1] College of Medicine, Department of Psychiatry, Korea University, Seoul 02841, Korea;Department of Mental Health, ASREM, 86039 Termoli, Italy;Department of Neurosciences and Imaging, Chair of Psychiatry, University “G. D’Annunzio”, 66100 Chieti, Italy;Department of Psychiatry, Federico II University, 80131 Naples, Italy;Department of Psychiatry, University of Foggia, 71121 Foggia, Italy;NHS, Department of Mental Health, Psychiatric Service for Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4, 64100 Teramo, Italy;NHS, Department of Mental Health, Psychiatric Service for Diagnosis and Treatment, Hospital “Maria SS. dello Splendore” ASL 4, 64021 Giulianova, Italy;Villa “S. Giuseppe” Clinic, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy;

关键词: gut microbiota;    bipolar disorder;    mood;    anxiety;    mania;    depression;   

DOI  :  10.3390/ijms22073723

来源: DOAJ

【 摘 要 】

The gut microbiota is the set of microorganisms that colonize the gastrointestinal tract of living creatures, establishing a bidirectional symbiotic relationship that is essential for maintaining homeostasis, for their growth and digestive processes. Growing evidence supports its involvement in the intercommunication system between the gut and the brain, so that it is called the gut–brain–microbiota axis. It is involved in the regulation of the functions of the Central Nervous System (CNS), behavior, mood and anxiety and, therefore, its implication in the pathogenesis of neuropsychiatric disorders. In this paper, we focused on the possible correlations between the gut microbiota and Bipolar Disorder (BD), in order to determine its role in the pathogenesis and in the clinical management of BD. Current literature supports a possible relationship between the compositional alterations of the intestinal microbiota and BD. Moreover, due to its impact on psychopharmacological treatment absorption, by acting on the composition of the microbiota beneficial effects can be obtained on BD symptoms. Finally, we discussed the potential of correcting gut microbiota alteration as a novel augmentation strategy in BD. Future studies are necessary to better clarify the relevance of gut microbiota alterations as state and disease biomarkers of BD.

【 授权许可】

Unknown