Data set of Aspergillus flavus induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection

Data in Brief

Venkatesh Prajna Namperumalsamy¹  Lalitha Prajna²  Chitra Thangavel³  Naveen Luke Demonte³  Jeyalakshmi Kandhavelu³  Dharmalingam Kuppamuthu³  Jeya Maheshwari Jayapal³ 

[1] Cornea Clinic, Aravind Eye Hospital, Aravind Eye Care System, Madurai, Tamil Nadu, India;Department of Ocular Microbiology, Aravind Eye Hospital, Aravind Eye Care System, Madurai, Tamil Nadu, India;Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, Tamil Nadu, India;

关键词: Mycotic keratitis;    Tear;    Inflammation;    Proteomics;    Glycosylation;    Complement;    NETosis;    Wound healing;   

DOI  :  10.1016/j.dib.2016.11.003

来源: DOAJ

【 摘 要 】

Fungal keratitis is one of the leading causes of blindness in the tropical countries affecting individuals in their most productive age. The host immune response during this infection is poorly understood. We carried out comparative tear proteome analysis of Aspergillus flavus keratitis patients and uninfected controls. Proteome was separated into glycosylated and non-glycosylated fractions using lectin column chromatography before mass spectrometry. The data revealed the major processes activated in the human host in response to fungal infection and reflected in the tear. Extended analysis of this dataset presented here complements the research article entitled “Aspergillus flavus induced alterations in tear protein profile reveal pathogen-induced host response to fungal infection [1]” (Jeyalakhsmi Kandhavelu, Naveen Luke Demonte, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Chitra Thangavel, Jeya Maheshwari Jayapal, Dharmalingam Kuppamuthu, 2016). The mass spectrometry proteomics data have been deposited in the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE:PXD003825.

【 授权许可】

Unknown