Sodium caseinate stabilized emulsions as a delivery system for epigallocatechin-gallate: Bioaccessibility, anti-proliferative activity and intestinal absorption

Journal of Functional Foods

Anilda Guri¹  Elena Arranz²  Milena Corredig²  Somayeh Sabouri² 

[1] Canadian Research Institute for Food Safety, University of Guelph, Guelph, ON N1G2W1, Canada;Department of Food Science, University of Guelph, Guelph, ON N1G 2W1, Canada;

关键词: Tea polyphenols;    Sodium caseinate emulsions;    Bioaccessibility;    Intestinal absorption;   

DOI  :  

来源: DOAJ

【 摘 要 】

The objective of this study was to investigate the effect of complexation of epigallocatechin-gallate (EGCG) to a caseinate-stabilized oil-water interface on the bioefficacy of EGCG. The bioaccessibility, anti-proliferative activity, and intestinal uptake of EGCG are reported. Higher amount of EGCG was present in digested emulsions compared to their equivalent solutions after digestion. The incorporation of EGCG in sodium caseinate emulsions improved its bioaccesibility and this was confirmed by cytotoxicity assays on Caco-2 cells. Intestinal absorption of EGCG was also studied with in vitro transport experiments. It was difficult to obtain a quantitative measurement of the EGCG in the basolateral fraction, but the fractions showed a clear anti-proliferative activity. These results would suggest the use of a cytotoxicity assay on cell cultures to estimate the extent of intestinal absorption of the bioactive catechin EGCG. The findings demonstrated that sodium caseinate-stabilized emulsions can be used as a platform for delivery of EGCG.

【 授权许可】

Unknown