Novel approaches to treatment of locally advanced rectal cancer

Тазовая хирургия и онкология

Yu. B. Karagodina¹  A. L. Kornietskaya¹  L. V. Bolotina¹  I. V. Droshneva¹  A. A. Fedenko¹  A. A. Kachmazov¹ 

[1] P. A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia;

关键词: rectal cancer;    locally advanced cancer;    watch-and-wait;    neoadjuvant therapy;    consolidation chemotherapy;   

DOI  :  10.17650/2686-9594-2020-10-3-4-73-83

来源: DOAJ

【 摘 要 】

Combination of neoadjuvant chemoradiotherapy with subsequent total mesorectum excision and 6-months of adjuvant chemotherapy remains a standard approach to treatment of locally advanced rectal cancer (T3 or T4 and / or N1–3; M0) for more than 15 years, which is reflected in practical guidelines of most leading oncological societies. However, recent data suggests possibilities of more individualized treatment conceptions with a potential of further improvement of long-term therapy outcomes and patient’s quality of life. In this paper we present review of results of clinical trials which investigated new approaches to treatment of locally advanced rectal cancer.

【 授权许可】

Unknown