Resting Metabolic Rate Does Not Change in Response to Different Types of Training in Subjects with Type 2 Diabetes

Frontiers in Endocrinology

Cecilie Fau Brinkløv¹  Mathias Ried-Larsen¹  Kristian Karstoft¹  Ida Kær Thorsen¹  Jens Steen Nielsen⁴ 

[1] Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Centre of Inflammation and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Endocrinology, Odense University Hospital, Odense, Denmark;OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark;

关键词: resting metabolic rate;    exercise interventions;    exercise training;    body composition;    physical fitness;    glycemic control;   

DOI  :  10.3389/fendo.2017.00132

来源: DOAJ

【 摘 要 】

Background and objectivesAmbiguous results have been reported regarding the effects of training on resting metabolic rate (RMR), and the importance of training type and intensity is unclear. Moreover, studies in subjects with type 2 diabetes (T2D) are sparse. In this study, we evaluated the effects of interval and continuous training on RMR in subjects with T2D. Furthermore, we explored the determinants for training-induced alterations in RMR.MethodsData from two studies, both including T2D subjects, were encompassed in this manuscript. Study 1 was a randomized, crossover study where subjects (n = 14) completed three, 2-week interventions [control, continuous walking training (CWT), interval-walking training (IWT)] separated by washout periods. Training included 10 supervised treadmill sessions, 60 min/session. CWT was performed at moderate walking speed [aiming for 73% of walking peak oxygen uptake (VO2peak)], while IWT was performed as alternating 3-min repetitions at slow (54% VO2peak) and fast (89% VO2peak) walking speed. Study 2 was a single-arm training intervention study where subjects (n = 23) were prescribed 12 weeks of free-living IWT (at least 3 sessions/week, 30 min/session). Before and after interventions, RMR, physical fitness, body composition, and glycemic control parameters were assessed.ResultsNo overall intervention-induced changes in RMR were seen across the studies, but considerable inter-individual differences in RMR changes were seen in Study 2. At baseline, total body mass (TBM), fat-free mass (FFM), and fat mass were all associated with RMR. Changes in RMR were associated with changes in TBM and fat mass, and subjects who decreased body mass and fat mass also decreased their RMR. No associations were seen between changes in physical fitness, glycemic control, or FFM and changes in RMR.ConclusionNeither short-term continuous or interval-type training, nor longer term interval training affects RMR in subjects with T2D when no overall changes in body composition are seen. If training occurs concomitant with a reduction in fat mass, however, RMR is decreased.Clinical Trials Registration (www.ClinicalTrials.gov)NCT02320526 and NCT02089477.

【 授权许可】

Unknown