Spirocyclic Motifs in Natural Products

Molecules

Olga Babich¹  Evgeny Chupakhin¹  Mikhail Krasavin¹  Lyudmila Asyakina²  Alexander Prosekov² 

[1] Immanuel Kant Baltic Federal University, 236016 Kaliningrad, Alexandra Nevskogo 14, Russia;Kemerovo State University, 650000 Krasnaya, Kemerovo, Russia;

关键词: natural products;    spirocycles;    chemical diversity;    biological activity;    privileged structures;   

DOI  :  10.3390/molecules24224165

来源: DOAJ

【 摘 要 】

Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with unique compounds reported in the literature has been undertaken. This review aims to fill that void and analyze the diversity of structurally unique natural products containing spirocyclic moieties of various sizes.

【 授权许可】

Unknown