Nutritionally variant streptococci causing endophthalmitis associated with intravitreal anti-vascular endothelial growth factor injection

American Journal of Ophthalmology Case Reports

Harry W. Flynn, Jr.¹  Darlene Miller¹  Daniela P. Reyes-Capo¹  Jesse D. Sengillo¹  Carsten Z. Steinmetz²  H. Logan Brooks²  Robert L. Steinmetz² 

[1] Department of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17th St., Miami, FL, USA;Southern Vitreoretinal Associates, 2439 Care Dr., Tallahassee, FL, USA;

关键词: Endophthalmitis;    Intravitreal injection;    Anti-VEGF;    Nutritionally variant streptococci;    Granulicatella adiacens;    Abiotrophia defectiva;   

DOI  :  

来源: DOAJ

【 摘 要 】

Purpose: To describe the clinical course and microbial properties of the first two reported cases of nutritionally variant Streptococci (Granulicatella adiacens and Abiotrophia defectiva) endophthalmitis following intravitreal anti-vascular endothelial growth factor injection (IVI). Observations: A 74 year-old female developed Granulicatella adiacens endophthalmitis following IVI. The patient underwent a pars plana vitrectomy and visual acuity recovered to 20/30 in six weeks. Similarly, an 88 year-old male developed Abiotrophia defectiva endophthalmitis after IVI. After a pars plana vitrectomy, the visual acuity recovered to 20/60 at five weeks. Conclusions and Importance: Endophthalmitis due to Streptococcus species has traditionally resulted in uniformly poor visual outcomes. However, nutritionally variant Streptococci, now reclassified as Granulicatella and Abiotrophia species, appear to have a less aggressive clinical course and better visual acuity outcomes. To the authors’ knowledge, these are the first reports of nutritionally variant Streptococci following IVI related endophthalmitis.

【 授权许可】

Unknown