Caprine Arthritis Encephalitis Virus Is Associated with Renal Lesions

Viruses

Omar Gonzales-Viera¹  Asli Mete¹  Helena Vogel²  Marietta Barro²  Brian G. Murphy²  Diego Castillo²  Dayna Goldsmith³ 

[1] California Animal Health and Food Safety Laboratory System, Davis Lab, 620 W Health Science Dr, Davis, CA 95616, USA;Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA;Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada;

关键词: SRLV;    CAEV;    TFBS;    lentivirus;    goat;    promoter;   

DOI  :  10.3390/v13061051

来源: DOAJ

【 摘 要 】

Caprine arthritis encephalitis virus (CAEV) is a monocyte/macrophage-tropic lentivirus that primarily infects goats resulting in a well-recognized set of chronic inflammatory syndromes focused on the joint synovium, tissues of the central nervous system, pulmonary interstitium and mammary gland. Clinically affected animals generally manifest with one or more of these classic CAEV-associated tissue lesions; however, CAEV-associated renal inflammation in goats has not been reported in the peer-reviewed literature. Here we describe six goats with chronic, multisystemic CAEV infections in conjunction with CAEV-associated renal lesions. One of the animals had CAEV antigen-associated thrombotic arteritis resulting in infarction of both the kidney and heart. These goats had microscopic evidence of inflammatory renal injury (interstitial nephritis) with detectable renal immunolabeling for CAEV antigen in three of six animals and amplifiable proviral sequences consistent with CAEV in all six animals. Cardiac lesions (vascular, myocardial or endocardial) were also identified in four of six animals. Within the viral promoter (U3) region, known transcription factor binding sites (TFBSs) were generally conserved, although one viral isolate had a duplication of the U3 A region encoding a second gamma-activated site (GAS). Despite the TFBS conservation, the isolates demonstrated a degree of phylogenetic diversity. At present, the clinical consequence of CAEV-associated renal injury is not clear.

【 授权许可】

Unknown