Egg white hydrolysate prevents reproductive impairments induced by cadmium in rats

Journal of Functional Foods

Marta Miguel¹  Fernando Barbosa, Junior²  Dalton Valentim Vassallo³  Caroline Silveira Martinez⁴  José Eudes Gomes Pinheiro, Júnior⁵  José Eduardo Stasiaki⁵  Franck Maciel Peçanha⁵  Giulia Alessandra Wiggers⁵  Paola Zambelli Moraes⁵  Maria Elisa Trost⁵  Francielli Weber Santos Cibin⁵ 

[1] Bioactivity and Food Analysis Laboratory, Instituto de Investigación en Ciencias de la Alimentación, Nicolás Cabrera, 9, Campus Universitario de Cantoblanco, Madrid, Spain;Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14049-903 Ribeirão Preto, São Paulo, Brazil;Departments of Physiological Sciences, Universidade Federal do Espírito Santo and School of Medicine of Santa Casa de Misericórdia (EMESCAM), Av. Marechal Campos 1468, Zip Code: 29040-090, Vitória, Espírito Santo, Brazil;Equipe MitoLab, Institut MitoVasc, Université d'Angers, CHU Bât IRIS/IBS, Rue des Capucins, 49933 Angers cedex 9, France;Graduate Program in Biochemistry, Universidade Federal do Pampa, BR 472 – Km 592 – PO Box 118, Zip Code: 97500-970, Uruguaiana, Rio Grande do Sul, Brazil;

关键词: Egg white hydrolysate;    Antioxidant;    Cadmium;    Oxidative stress;    Reproductive system;   

DOI  :  

来源: DOAJ

【 摘 要 】

Here, we investigated the ability of an egg white hydrolysate (EWH) to counteract the reproductive toxic effects induced by Cd in rats. 3-month-old male Wistar rats were treated for 14 days: (a) Untreated group (distilled water i.p.); (b) Cd group (CdCl2 at 1 mg/kg body weight i.p.); (c) EWH group (1 g/kg body weight/day per gavage); (d) CdEWH group (CdCl2 with EWH). Cd exposure was able to be accumulated in testis and epididymis, increasing oxidative stress and compromising sperm quality and daily sperm production. Co-treatment with EWH prevented increased deposition of Cd in testis (Untreated: 0.04 ± 0.02; Cd: 4.68 ± 1.03*; EWH: 0.01 ± 0.00; CdEWH: 1.85 ± 0.25# μg Cd/g dry tissue p < 0.05; *vs Untreated; #vs Cd), prevented reduction of sperm motility and the increased oxidative stress. Therefore, EWH could represent a powerful natural alternative to protect the male reproductive system against Cd-induced toxicity.

【 授权许可】

Unknown