Oncogenic Properties of the EBV ZEBRA Protein

Cancers

Emmanuel Drouet¹  Yegor Vassetzky²  Diego Germini²  Svetlana Dokudovskaya²  FatimataBintou Sall²  Anna Shmakova²  Joëlle Wiels² 

[1] CIBB-IBS UMR 5075 Université Grenoble Alpes, 38044 Grenoble, France;CNRS UMR9018, Université Paris-Saclay, Institut Gustave Roussy, 94805 Villejuif, France;

关键词: EBV;    ZEBRA;    Zta;    BZLF1;    lytic cycle;    viral-host interaction;   

DOI  :  10.3390/cancers12061479

来源: DOAJ

【 摘 要 】

Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary infection, it can persist in the host throughout their lifetime in a latent form, from which it can reactivate following specific stimuli. EBV reactivation is triggered by transcriptional transactivator proteins ZEBRA (also known as Z, EB-1, Zta or BZLF1) and RTA (also known as BRLF1). Here we discuss the structural and functional features of ZEBRA, its role in oncogenesis and its possible implication as a prognostic or diagnostic marker. Modulation of host gene expression by ZEBRA can deregulate the immune surveillance, allow the immune escape, and favor tumor progression. It also interacts with host proteins, thereby modifying their functions. ZEBRA is released into the bloodstream by infected cells and can potentially penetrate any cell through its cell-penetrating domain; therefore, it can also change the fate of non-infected cells. The features of ZEBRA described in this review outline its importance in EBV-related malignancies.

【 授权许可】

Unknown