Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings

Molecules

Nicolai A. Aksenov¹  Dmitrii A. Aksenov¹  Alexander V. Aksenov¹  Michael Rubin¹  Nikita K. Kirilov¹  Carolyn Lower²  Elena A. Sorokina³ 

[1] Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia;Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA;Organic Chemistry Department, Peoples’ Friendship, University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia;

关键词: nitroalkanes;    heterocycles;    annulation;    cascade transformations;   

DOI  :  10.3390/molecules26185692

来源: DOAJ

【 摘 要 】

Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents.

【 授权许可】

Unknown