Frontiers in Psychiatry | |
Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment | |
Kenji Matsumoto1  Madoka Matsumoto2  Tomiki Sumiyoshi3  Satoru Ikezawa4  Kazuyoshi Takeda4  Kazuyuki Nakagome5  Kou Murayama6  | |
[1] Brain Science Institute, Tamagawa University, Tokyo, Japan;Department of Neuropsychiatry, The University of Tokyo Hospital, Tokyo, Japan;Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan;Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan;National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan;Research Institute, Kochi University of Technology, Kochi, Japan;School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom; | |
关键词: intrinsic motivation; cognitive remediation therapy; schizophrenia; lateral prefrontal cortex; striatum; self-determination theory; | |
DOI : 10.3389/fpsyt.2018.00178 | |
来源: DOAJ |
【 摘 要 】
The ultimate goal of the treatment of schizophrenia is recovery, a notion related to improvement of cognitive and social functioning. Cognitive remediation therapies (CRT), one of the most effective cognition enhancing methods, have been shown to moderately improve social functioning. For this purpose, intrinsic motivation, related to internal values such as interest and enjoyment, has been shown to play a key role. Although the impairment of intrinsic motivation is one of the characteristics of schizophrenia, its neural mechanisms remain unclear. This is related to the lack of feasible measures of intrinsic motivation, and its response to treatment. According to the self-determination theory (SDT), not only intrinsic motivation, but extrinsic motivation has been reported to enhance learning and memory in healthy subjects to some extent. This finding suggests the contribution of different types of motivation to potentiate the ability of the CRT to treat cognitive impairment of schizophrenia. In this paper, we provide a review of psychological characteristics, assessment methods, and neural correlates of intrinsic motivation in healthy subjects and patients with schizophrenia. Particularly, we focus on neuroimaging studies of intrinsic motivation, including our own. These considerations are relevant to enhancement of functional outcomes of schizophrenia.
【 授权许可】
Unknown