Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats

Bioengineering

Pedro Tralhão¹  Carlos Miguel Marto²  Maria Filomena Botelho²  Mafalda Laranjo²  Karla Menezes Cardoso³  Tarcísio Guerra Guimarães³  Nuno Alexandre⁴ 

[1]Center of Veterinary Ophthalmology, Oftalvet, 4050-102 Porto, Portugal

[2]Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal

[3]Institute of Research and Advanced Training (IIFA), University of Évora, 7002-554 Évora, Portugal

[4]Mediterranean Institute for Agriculture, Environment and Development (MED), University of Évora, 7006-554 Évora, Portugal

关键词: melanocytic neoplasms;    melanoma;    therapeutics;   

DOI  :  10.3390/bioengineering8120225

来源: DOAJ

【 摘 要 】

Neoplasms of melanocytic origin are diseases relevant to dogs and cats’ ophthalmic oncology due to their incidence, potential visual loss, and consequent decrease in life quality and expectancy. Despite its non-specific clinical presentation, melanocytic neoplasms can be histologically distinguished in melanocytomas, which present benign characteristics, and malignant melanomas. The diagnosis often occurs in advanced cases, limiting the therapeutic options. Surgery, cryotherapy, radiotherapy, photodynamic therapy (PDT), and laser are currently available therapeutic strategies. As no clinical guidelines are available, the treatment choice is primarily based on the clinician’s preference, proficiency, and the owner’s financial constraints. While surgery is curative in benign lesions, ocular melanomas present a variable response to treatments, besides the potential of tumour recurrences or metastatic disease. This review presents the currently available therapies for ocular melanocytic neoplasms in dogs and cats, describing the therapeutic, indications, and limitations. Additionally, new therapeutics being developed are presented and discussed, as they can improve the current treatment options.

【 授权许可】

Unknown