From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

Molecules

Marta Correia-da-Silva¹  Emília Sousa¹  Andreia Palmeira¹  Honorina Cidade¹  Sara Cravo¹  MariaElizabeth Tiritan¹  DianaI. S. P. Resende¹  Carla Fernandes¹  MadalenaM. M. Pinto¹ 

[1] Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;

关键词: xanthones;    thioxanthones;    marine natural products;    biological activities;    synthesis;    chiral;   

DOI  :  10.3390/molecules26020431

来源: DOAJ

【 摘 要 】

This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has been in the xanthone family. Xanthone derivatives have a variety of activities with great potential for therapeutic applications due to their versatile framework. The group has contributed with several libraries of xanthones derivatives, with a variety of activities such as antitumor, anticoagulant, antiplatelet, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective, antioxidant, and multidrug resistance reversal effects. Besides therapeutic applications, our group has also developed xanthone derivatives with analytical applications as chiral selectors for liquid chromatography and for maritime application as antifouling agents for marine paints. Chemically, it has been challenging to afford green chemistry methods and achieve enantiomeric purity of chiral derivatives. In this review, the structures of the most significant compounds will be presented.

【 授权许可】

Unknown