A Systematic Review and Critical Analysis of the Role of Graphene-Based Nanomaterials in Cancer Theranostics

Pharmaceutics

Teresa Viseu¹  Eduarda Fernandes¹  Marlene Lúcio¹  MariaElisabete C.D. Real Oliveira¹  CarlaM. Lopes² 

[1] CF-UM-UP—Centre of Physics of Universities of Minho and Porto, Departament of Physics of University of Minho, Escola de Ciências, Campus de Gualtar, 4710-057 Braga, Portugal;FP-ENAS/CEBIMED—Fernando Pessoa Energy, Environment and Health Research Unit/Biomedical Research Centre, Faculty of Health Sciences, Fernando Pessoa University, 4249-004 Porto, Portugal;

关键词: systematic review;    graphene-based materials;    graphene oxide;    reduced graphene oxide;    nano-graphene;    graphene quantum dots;    theranostics;    cancer;   

DOI  :  10.3390/pharmaceutics10040282

来源: DOAJ

【 摘 要 】

Many graphene-based materials (GBNs) applied to therapy and diagnostics (theranostics) in cancer have been developed. Most of them are hybrid combinations of graphene with other components (e.g., drugs or other bioactives, polymers, and nanoparticles) aiming toward a synergic theranostic effect. However, the role of graphene in each of these hybrids is sometimes not clear enough and the synergic graphene effect is not proven. The objective of this review is to elaborate on the role of GBNs in the studies evaluated and to compare the nanoformulations in terms of some of their characteristics, such as therapeutic outcomes and toxicity, which are essential features for their potential use as bionanosystems. A systematic review was carried out using the following databases: PubMed, Scopus, and ISI Web of Science (2013⁻2018). Additional studies were identified manually by consulting the references list of relevant reviews. Only English papers presenting at least one strategy for cancer therapy and one strategy for cancer diagnostics, and that clearly show the role of graphene in theranostics, were included. Data extraction and quality assessment was made by reviewer pairings. Fifty-five studies met the inclusion criteria, but they were too heterogeneous to combine in statistical meta-analysis. Critical analysis and discussion of the selected papers are presented.

【 授权许可】

Unknown