Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment

Frontiers in Aging Neuroscience

Liliana Vargas¹  Juan P. Tartari¹  Itziar de Rojas¹  Ana Mauleón¹  Maitee Rosende-Roca¹  Rogelio López-Cuevas¹  Laura Montrreal¹  Urszula Bojaryn¹  Alba Pérez-Cordón¹  Sonia Moreno-Grau¹  Ester Esteban de Antonio¹  Emilio Alarcón-Martín¹  Adelina Orellana²  Natalia Roberto²  Maria J. Portella⁴  Marta Marquié⁵  Montserrat Alegret⁵  Agustín Ruíz⁵  Mercè Boada⁵  Ana Espinosa⁵  Sergi Valero⁵  Isabel Hernández⁵  Gemma Ortega⁵  Carla Abdelnour⁵  Lluís Tárraga⁵  Ángela Sanabria⁵ 

[1] Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain;Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain;Department of Psychiatry, Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;Networking Research Center on Mental Health (CIBERSAM), Madrid, Spain;Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain;

关键词: mild cognitive impairment;    cognitive decline;    neuropsychiatric symptoms;    irritability;    apathy;    anxiety;   

DOI  :  10.3389/fnagi.2021.718949

来源: DOAJ

【 摘 要 】

Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia.Objective: The aim of this study was to explore the trajectories of cognitive decline in an MCI sample from a memory clinic, taking into consideration a perspective of isolated cognitive functions and based on NPS clusters, accounting for the different comorbid symptoms collected at their baseline visit.Methods: A total of 2,137 MCI patients were monitored over a 2.4-year period. Four clusters of NPS (i.e., Irritability, Apathy, Anxiety/Depression and Asymptomatic) were used to run linear mixed models to explore the interaction of cluster with time on cognitive trajectories using a comprehensive neuropsychological battery (NBACE) administered at baseline and at the three subsequent follow-ups.Results: A significant interaction between cluster and time in cognitive decline was found when verbal learning and cued-recall were explored (p = 0.002 for both memory functions). For verbal learning, the Irritability cluster had the largest effect size (0.69), whereas the Asymptomatic cluster showed the smallest effect size (0.22). For cued-recall, the Irritability cluster had the largest effect size among groups (0.64), and Anxiety/Depression had the smallest effect size (0.21).Conclusions: In MCI patients, the Irritability and Apathy NPS clusters shared similar patterns of worsening in memory functioning, which could point to these NPS as risk factors of a faster cognitive decline, acting as early prognostic markers and helping in the diagnostic process.

【 授权许可】

Unknown