Turn it off and on again: characteristics and control of torpor [version 2; peer review: 2 approved, 1 approved with reservations, 1 not approved]

Wellcome Open Research

Timna Hitrec¹  Michael Ambler¹  Anthony Pickering¹ 

[1] School of Physiology, Pharmacology, & Neuroscience, University of Bristol, Bristol, Bristol, BS8 1TD, UK;

关键词: Torpor;    Metabolism;    Homeostasis;    Thermoregulation;    Hibernation;    Energy balance;    eng;   

DOI  :  

来源: DOAJ

【 摘 要 】

Torpor is a hypothermic, hypoactive, hypometabolic state entered into by a wide range of animals in response to environmental challenge. This review summarises the current understanding of torpor. We start by describing the characteristics of the wide-ranging physiological adaptations associated with torpor. Next follows a discussion of thermoregulation, control of food intake and energy expenditure, and the interactions of sleep and thermoregulation, with particular emphasis on how those processes pertain to torpor. We move on to review the evidence for the systems that control torpor entry, including both the efferent circulating factors that signal the need for torpor, and the central processes that orchestrate it. Finally, we consider how the putative circuits responsible for torpor induction integrate with the established understanding of thermoregulation under non-torpid conditions and highlight important areas of uncertainty for future studies.

【 授权许可】

Unknown