Successful healing of non-healing surgical wound based on the release of platelet-derived growth factors from single donor allogeneic platelet-RICH plasma with one freeze-thaw cycle: a case report after a 1-year follow-up

Translational Medicine Communications

Jesús Seco-Calvo¹  Sergio Sánchez-Herráez²  Julia Vidán-Estévez³ 

[1] Institute of Biomedicine (IBIOMED), University of León;Servicio de Cirugía y Traumatología Ortopédica, Complejo Asistencial Universitario de León (CAULE);Servicio de Transfusión. Complejo Asistencial Universitario de León (CAULE);

关键词: Non-healing surgical wound;    Platelet-derived growth factors (PDGF);    Freeze-thaw process;    Allogenic plasma-rich-platelet (al-PRP);    Single donor apheresis;   

DOI  :  10.1186/s41231-022-00120-w

来源: DOAJ

【 摘 要 】

Abstract Background Non-healing surgical wounds is a risk in certain patients. Recently, allogenic plasma-rich-platelet (PRP) is used such as regenerative treatment of different non-healing surgical wounds. Purpose We explore the potential role of using platelet-derived growth factors from single donor PRP, with a freeze-thaw process, for the treatment of surgical scar ulcer. Methods We have used a PRP preparation protocol that involved a single cycle of centrifugation at a mean speed of 2400–2800 rpm of donor blood taken with an apheresis machine. Results To our knowledge, this is the first study using the platelet-derived growth factors (PDGF) from single donor apheresis, with a freeze-thaw process. Four weeks after daily application of al-PRP, the ulcer progressed satisfactorily; at six weeks, the ulcer had healed. Conclusion We concluded that the healing of a surgical wound observed in our case, is promising and suggests that al-PRP might play a role in treating surgical scar ulcers. This must be confirmed in future studies.

【 授权许可】

Unknown