Presynaptic long-term plasticity

Frontiers in Synaptic Neuroscience

Nicole eCalakos¹  Ying eYang² 

[1] Duke University;Stanford University;

关键词: synaptic plasticity;    neurotransmitter release;    long-term potentiation (LTP);    presynaptic plasticity;    synaptic vesicle;    long-term depression (LTD);   

DOI  :  10.3389/fnsyn.2013.00008

来源: DOAJ

【 摘 要 】

Long-term synaptic plasticity is a major cellular substrate for learning, memory, and behavioral adaptation. Although early examples of long-term synaptic plasticity described a mechanism by which postsynaptic signal transduction was potentiated, it is now apparent that there is a vast array of mechanisms for long-term synaptic plasticity that involve modifications to either or both the presynaptic terminal and postsynaptic site. In this article, we discuss current and evolving approaches to identify presynaptic mechanisms as well as discuss their limitations. We next provide examples of the diverse circuits in which presynaptic forms of long-term synaptic plasticity have been described and discuss the potential contribution this form of plasticity might add to circuit function. Finally, we examine the present evidence for the molecular pathways and cellular events underlying presynaptic long-term synaptic plasticity.

【 授权许可】

Unknown