Iron Deficiency Anemia in Pregnancy: Novel Approaches for an Old Problem

Oman Medical Journal

Patrizia Maria Cacciato¹  Calogero Salvaggio²  Maria Magliarditi³  Simone Garzon⁴  Camilla Certelli⁵  Gianluca Rizzo⁶ 

[1] Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy;Department of Obstetrics and Gynecology, Azienda Sanitaria Provinciale 2 Caltanissetta, Sant’Elia Hospital, Caltanissetta, Italy;Department of Obstetrics and Gynecology, Policlinico Universitario Gazzi, University of Messina, Messina, Italy;Department of Obstetrics and Gynecology, University of Insubria, Filippo Del Ponte Hospital, Varese, Italy;Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, Regina Elena National Cancer Institute, Rome, Italy;Independent Researcher, Messina, Italy;

关键词: anemia;    iron-deficiency;    pregnancy;    iron;    pregnancy outcome;    prenatal care;   

DOI  :  10.5001/omj.2020.108

来源: DOAJ

【 摘 要 】

Iron needs increase exponentially during pregnancy to meet the increased demands of the fetoplacental unit, to expand maternal erythrocyte mass, and to compensate for iron loss at delivery. In more than 80% of countries in the world, the prevalence of anemia in pregnancy is > 20% and could be considered a major public health problem. The global prevalence of anemia in pregnancy is estimated to be approximately 41.8%. Undiagnosed and untreated iron deficiency anemia (IDA) can have a great impact on maternal and fetal health. Indeed, chronic iron deficiency can affect the general wellbeing of the mother and leads to fatigue and reduced working capacity. Given the significant adverse impact on maternal-fetal outcomes, early recognition and treatment of this clinical condition is fundamental. Therefore, the laboratory assays are recommended from the first trimester to evaluate the iron status. Oral iron supplementation is the first line of treatment in cases of mild anemia. However, considering the numerous gastrointestinal side effects that often lead to poor compliance, other therapeutic strategies should be evaluated. This review aims to provide an overview of the current evidence about the management of IDA in pregnancy and available treatment options.

【 授权许可】

Unknown