Mental disorders and cognitive impairment in patients with antiphospholipid syndrome

Терапевтический архив

T. M. Reshetnyak¹  O. B. Kovalevskaya²  V. N. Krasnov³  A. B. Borisova³  D. Yu. Veltishchev³  E. L. Nasonov³  T. A. Lisitsyna⁴  O. F. Seravina⁴ 

[1] Pirogov Russian National Research Medical University;Russian Medical Academy of Continuous Professional Education;Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction;Nasonova Research Institute of Rheumatology;

关键词: antiphospholipid syndrome;    mental disorders;    cognitive impairment;    antiphospholipid antibodies;    inflammation;    stress factors;    pathogenesis;    diagnosis;    therapy;   

DOI  :  10.26442/00403660.2020.05.000625

来源: DOAJ

【 摘 要 】

Mental disorders (mainly anxiety and depressive disorders) and cognitive impairment are often found in patients with antiphospholipid syndrome (APS), but their prevalence, structure, and mechanisms of occurrence are not well researched. The review provides literature data on the frequency, spectrum and possible causes of mental disorders and cognitive impairment in patients with APS, the pathogenetic mechanisms of these disorders (in particular, the important role of antiphospholipid antibodies, stress factors, chronic inflammation), the relationship between APS, mental disorders and as well as cognitive impairment is examined. Special attention is paid to the influence of mental disorders and cognitive impairment on patients adherence to treatment, their quality of life, as well as the particularities of psychopharmacotherapy of mental disorders in patients with APS. The aim of the review is to actualize the interdisciplinary problem of mental disorders and cognitive impairment in patients with APS and the need to introduce a partnership model of care.

【 授权许可】

Unknown