Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers

BMC Cancer

Xiaofeng Xu¹  Xuefei Li²  Chao Zhao²  Guanghui Gao³  Fengying Wu³  Tao Jiang³  Fei Zhou³  Meng Qiao³  Caicun Zhou³  Chunxia Su³  Shengxiang Ren³  Xiaoxia Chen³  Changyun Zhai⁴ 

[1] Department of Clinical Laboratory, Fudan University Shanghai Cancer Center;Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine;Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine;Department of Medical Oncology, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine;

关键词: CD73;    Cancer;    Immunotherapy;    Prognosis;    Characterization;    Meta-analysis;   

DOI  :  10.1186/s12885-018-4073-7

来源: DOAJ

【 摘 要 】

Abstract Background CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers. Methods PubMed, Web of Science, EMBASE and Cochrane library were searched to identify the relevant studies. CD73 expression level in distinct cancers and its relationship with clinicopathlogical characteristics and prognosis were investigated using online database. Meta-analyses were conducted using RevMan v5.0 and STATA v12.0. Results Fourteen publications with 2951 cases were included. The incidence of high CD73 expression was 0.50 (95% CI: 0.36–0.63). Data from Oncomine validated that median CD73 expression level in tumor tissues was markedly higher than that in normal tissues in most kinds of cancers except cecum adenocarcinoma and ovarian cancer (P < 0.05). High CD73 expression was significantly correlated with shorter overall survival (OS) in various cancers (high risk [HR] = 1.48; P < 0.05). Subgroup analysis using online database demonstrated that high CD73 expression was significantly correlated with poor OS in breast (HR = 1.23; P < 0.05) and ovarian cancer (HR = 1.14; P < 0.05), but favorable OS in lung (HR = 0.80; P < 0.05) and gastric cancer (HR = 0.71; P < 0.05). High CD73 expression was dramatically associated with lymph node metastases (OR = 2.61; P = 0.05). Conclusion High CD73 expression was significantly associated with lymph node metastases and a promising prognostic factor in different types of cancers.

【 授权许可】

Unknown