Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity

Molecules

Jadwiga Handzlik¹  Małgorzata Anna Marć¹  Wesam Ali²  Mónica Álvarez-Pérez³  Enrique Domínguez-Álvarez³ 

[1] Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland;Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B2 1, D-66123 Saarbruecken, Germany;Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG, CSIC), Juan de la Cierva 3, 28006 Madrid, Spain;

关键词: selenium;    selenocompounds;    selenides;    diselenides;    antioxidants;    chemoprevention;    anticancer compounds;    cytotoxicity;    cytostaticity;   

DOI  :  10.3390/molecules23030628

来源: DOAJ

【 摘 要 】

Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide due to their promising potential applications in cancer prevention and/or treatment. Different organic selenocompounds, with diverse functional groups that contain selenium, have been reported to exhibit anticancer and/or chemopreventive activity. Among them, selenocyanates, selenoureas, selenoesters, selenium-containing heterocycles, selenium nanoparticles, selenides and diselenides have been considered in the search for efficiency in prevention and treatment of cancer and other related diseases. In this review, we focus our attention on the potential applications of selenides and diselenides in cancer prevention and treatment that have been reported so far. The around 80 selenides and diselenides selected herein as representative compounds include promising antioxidant, prooxidant, redox-modulating, chemopreventive, anticancer, cytotoxic and radioprotective compounds, among other activities. The aim of this work is to highlight the possibilities that these novel organic selenocompounds can offer in an effort to contribute to inspire medicinal chemists in their search of new promising derivatives.

【 授权许可】

Unknown