Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification

International Journal of Molecular Sciences

Young-Kook Kim¹  Hyun Kook²  Juhee Ryu²  Duk-Hwa Kwon² 

[1] Department of Biochemistry, Chonnam National University Medical School, Hwasun 58128, Korea;Department of Pharmacology, Chonnam National University Medical School, Hwasun 58128, Korea;

关键词: histone deacetylase;    histone modifiers;    epigenetic regulator;    vascular calcification;    vascular smooth muscle cells;    post-translational modification;   

DOI  :  10.3390/ijms21093246

来源: DOAJ

【 摘 要 】

Vascular calcification (VC) is characterized by calcium deposition inside arteries and is closely associated with the morbidity and mortality of atherosclerosis, chronic kidney disease, diabetes, and other cardiovascular diseases (CVDs). VC is now widely known to be an active process occurring in vascular smooth muscle cells (VSMCs) involving multiple mechanisms and factors. These mechanisms share features with the process of bone formation, since the phenotype switching from the contractile to the osteochondrogenic phenotype also occurs in VSMCs during VC. In addition, VC can be regulated by epigenetic factors, including DNA methylation, histone modification, and noncoding RNAs. Although VC is commonly observed in patients with chronic kidney disease and CVD, specific drugs for VC have not been developed. Thus, discovering novel therapeutic targets may be necessary. In this review, we summarize the current experimental evidence regarding the role of epigenetic regulators including histone deacetylases and propose the therapeutic implication of these regulators in the treatment of VC.

【 授权许可】

Unknown