Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Ocular Therapy

Polymers

Bogdan-C. Iacob¹  Ede Bodoki¹  Andreea E. Bodoki²  Elena Dinte³  Oliviu Vostinaru⁴  Ovidiu Samoila⁵ 

[1] Department of Analytical Chemistry, “Iuliu Hatieganu” University of Medicine & Pharmacy, 400349 Cluj-Napoca, Romania;Department of General and Inorganic Chemistry, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania;Department of Pharmaceutical Technology and Biopharmaceutics, “Iuliu Hatieganu” University of Medicine & Pharmacy, 400012 Cluj-Napoca, Romania;Department of Pharmacology, Physiology and Physiopathology, “Iuliu Hatieganu” University of Medicine & Pharmacy, 400349 Cluj-Napoca, Romania;Ophthalmology Clinic Cluj, “Iuliu Hatieganu” University of Medicine & Pharmacy, 400006 Cluj-Napoca, Romania;

关键词: molecularly imprinted polymers;    drug delivery systems;    controlled release;    eye diseases;    functional polymers;   

DOI  :  10.3390/polym13213649

来源: DOAJ

【 摘 要 】

Although the human eye is an easily accessible sensory organ, it remains a challenge for drug administration due to the presence of several anatomical and physiological barriers which limit the access of drugs to its internal structures. Molecular imprinting technology may be considered the avant-garde approach in advanced drug delivery applications and, in particular, in ocular therapy. In fact, molecularly imprinted polymers hold the promise to compensate for the current shortcomings of the available arsenal of drug delivery systems intended for ocular therapy. The present manuscript aims to review the recent advances, the current challenges and most importantly to raise awareness on the underexplored potential and future perspectives of molecularly imprinted polymer-based drug delivery systems intended for the treatment of eye diseases.

【 授权许可】

Unknown