Low Protein Diets and Energy Balance: Mechanisms of Action on Energy Intake and Expenditure

Frontiers in Nutrition

Adel Pezeshki¹  Prasanth K. Chelikani² 

[1] Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, United States;Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, TX, United States;School of Veterinary Medicine, Texas Tech University, Amarillo, TX, United States;

关键词: low protein;    food intake;    energy expenditure;    neuroendocrine;    energy balance;   

DOI  :  10.3389/fnut.2021.655833

来源: DOAJ

【 摘 要 】

Low protein diets are associated with increased lifespan and improved cardiometabolic health primarily in rodents, and likely improve human health. There is strong evidence that moderate to severe reduction in dietary protein content markedly influences caloric intake and energy expenditure, which is often followed by a decrease in body weight and adiposity in animal models. While the neuroendocrine signals that trigger hyperphagic responses to protein restriction are better understood, there is accumulating evidence that increased sympathetic flux to brown adipose tissue, fibroblast growth factor-21 and serotonergic signaling are important for the thermogenic effects of low protein diets. This mini-review specifically focuses on the effect of low protein diets with variable carbohydrate and lipid content on energy intake and expenditure, and the underlying mechanisms of actions by these diets. Understanding the mechanisms by which protein restriction influences energy balance may unveil novel approaches for treating metabolic disorders in humans and improve production efficiency in domestic animals.

【 授权许可】

Unknown