Response Activation and Inhibition in Patients With Prolactinomas: An Electrophysiological Study

Frontiers in Human Neuroscience

Shun Yao²  Guozheng Xu³  Jian Song³  Lianting Ma³  Michael P. Catalino⁴  Yu Wang⁵  Chenglong Cao⁶  Deqi Yan⁷ 

[1] Center for Pituitary Tumor Surgery, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States;Department of Neurosurgery, The General Hospital of Chinese People’s Liberation Army Central Theater Command, Wuhan, China;Department of Neurosurgery, University of North Carolina, Chapel Hill, NC, United States;Key Laboratory of Cognitive Science, College of Biomedical Engineering, South- Central University for Nationalities, Wuhan, China;The First School of Clinical Medicine, Southern Medical University, Guangzhou, China;Traditional Chinese Medicine College, Xinjiang Medical University, Urumqi, China;

关键词: prolactinoma;    ERPs;    response activation;    response inhibition;    P300;   

DOI  :  10.3389/fnhum.2020.00170

来源: DOAJ

【 摘 要 】

Impairment of executive function has been reported in patients with prolactinomas. However, few studies have investigated the electrophysiological mechanisms of response activation and response inhibition in these patients. In this study, we employ an event-related potentials (ERPs) technique to quantitatively assess response activation and inhibition before and after the surgical treatment of prolactinomas. A 64-electrode electroencephalogram (EEG) skullcap was used to record the brain activity in 20 pre-operative patients, 20 follow-up post-operative patients, and 20 healthy controls (HCs) while performing the visual Go/Nogo task. As expected, we identified P300 across all study populations that could reflect response activation and inhibition. Across the three groups, the Nogo stimuli evoked larger frontal-central P300 than the Go stimuli did. In contrast, the Go trials elicited larger parietal P300 than the Nogo trials did. The peak latency of P300 was significantly delayed in both the pre-operative and the post-operative groups compared to the HCs. The amplitude of P300 in both the Go and the Nogo conditions was significantly decreased in the pre-operative patients compared with that of the HCs. At 6 months post-operatively, the prolactinoma patients showed an increase in amplitude of P300 during both the Go and the Nogo tasks. These findings indicate that the prolactinoma patients suffer from deficits in response activation and inhibition, which could be improved by surgical treatment.

【 授权许可】

Unknown