Detection of Anti-Echinococcus granulosus Antibodies in Humans: An Update from Pakistan

Pathogens

Huma Khan¹  Haroon Ahmed¹  Muhammad Khurram²  Muhammad Sohail Afzal²  Usman Ayub Awan³  Sami Simsek⁴  Jianping Cao⁵ 

[1] Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan;Department of Life Sciences, School of Science, University of Management & Technology (UMT), Lahore 54700, Pakistan;Department of Medical Laboratory Technology, The University of Haripur, Haripur 22620, Pakistan;Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, Elazig 23119, Turkey;National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, China;

关键词: cystic echinococcosis;    hydatid cysts;    seropositivity;    ELISA;    IHA;    Pakistan;   

DOI  :  10.3390/pathogens11010029

来源: DOAJ

【 摘 要 】

Human cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of Echinococcus granulosus sensu lato that causes economic losses by affecting livestock and also poses a public health threat worldwide. The present study is the first retrospective report on the seroprevalence of anti-E. granulosus antibodies in humans in Pakistan. The study used data from 93 blood analysis reports of patients suspected of having CE from different medical centers in Lahore, Pakistan. Out of 93 sera samples, 20 (21.5%) were seropositive, and higher seropositivity (17.2%) was recorded with the indirect hemagglutination test (IHA) than with enzyme-linked immunosorbent assay (ELISA). The findings indicated that age, gender, and year had no significant relationship with the seropositivity of CE. The current study provides directions towards the management of the disease in the near future in Pakistan.

【 授权许可】

Unknown