Antifungal activity of microcapsule propolis from Tetragonula spp. to Candida albicans

Communications in Science and Technology

MuhamadSahlan¹  PaksiPujianto¹  SitiFarida²  Iis Istikomah³  TetiIndrawati³  Diah Kartika Pratami⁴ 

[1] Department of Chemical Engineering, Faculty of Engineering, Depok, 16424, Universitas Indonesia;Department of Medical Pharmacy, Faculty of Medicine, Jakarta, 10430, Indonesia;Faculty of Pharmacy, National Institute of Science and Technology (ISTN), South Jakarta, 12640, Indonesia;Lab of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Pancasila University, South Jakarta, 12640, Indonesia;

关键词: candida albicans;    microencapsulation;    propolis;    spray drying;   

DOI  :  10.21924/cst.5.1.2020.178

来源: DOAJ

【 摘 要 】

Propolis is a mixture of resin and saliva of Tetragonula spp. that have antifungal activity. The purpose of this study was to develop spray-dried microcapsule propolis (SDMP) and to analyze its antifungal activity to Candida albicans. The SDMP was obtained using a spray drying method by maltodextrin and gum arabic coating. The antifungal activity of SDMP of rough propolis (taken from the outside beehive) and smooth propolis (taken from the inside beehive) was analyzed. The macroscopic characterization showed that SDMP has a powder form with brownish-yellow color. The microscopic characterization showed SDMP has a spherical uniform particle shape with particle size 9.32 - 14.61 µm. The encapsulation efficiency of smooth and rough SDMP was 81.22% and 83.04%; moisture content 5.58% and 5.84%; water solubility 98.19% and 98.31%, respectively. The microbial inhibitory concentration to C. albicans was the diameter of 6.33±1.5 to 10±2.5 mm. SDMP displayed remarkable activity in the assays against C. albicans.

【 授权许可】

Unknown