Frontiers in Psychiatry | |
Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent | |
Yoshihisa Koyama1  Shoichi Shimada1  Yukiko Nakamura1  Noriyoshi Usui1  Kazumasa Matsumoto-Miyai4  Yuki Kobayashi5  Hikaru Kobayashi5  | |
[1] Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan;Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, Japan;Global Center for Medical Engineering and Informatics, Osaka University, Suita, Japan;Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan;Institute of Scientific and Industrial Research, Osaka University, Suita, Japan;United Graduate School of Child Development, Osaka University, Suita, Japan; | |
关键词: maternal immune activation (MIA); neurodevelopmental disorders (NDDs); autism spectrum disorder (ASD); ultrasonic vocalization (USV); social communication; inflammation; | |
DOI : 10.3389/fpsyt.2022.872302 | |
来源: DOAJ |
【 摘 要 】
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we have developed a silicon (Si)-based hydrogen-producing antioxidant (Si-based agent) that continuously and effectively produces hydrogen in the body. Medical hydrogen is known to have antioxidative, anti-inflammatory, and antiapoptotic effects, therefore we applied our Si-based agent as a potential therapeutic agent to MIA. Using a MIA mouse model, we found that the Si-based agent improved the social communication of MIA offspring mice. We also found that the Si-based agent suppressed the expressions of inflammation-associated genes Ifna1 and Il-6 in the mouse brain. These results demonstrate that the Si-based agent is an effective prophylactic agent against MIA during pregnancy, suggesting that our Si-based agent may be a preventative or therapeutic agent for ASD and other disease risks in child health suppressing MIA damage.
【 授权许可】
Unknown