Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response

Viruses

Jing-hsiung James Ou¹  Stephanie T. Chan¹ 

[1] Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA;

关键词: hepatitis C virus;    autophagy;    innate immunity;   

DOI  :  10.3390/v9080224

来源: DOAJ

【 摘 要 】

Autophagy is a catabolic process that is important for maintaining cellular homeostasis. This pathway in hepatocytes is stimulated and controlled by the hepatitis C virus (HCV)—upon infection—to promote its own replication. HCV induces autophagy indirectly and directly through different mechanisms and temporally controls the autophagic flux. This enables the virus to maximize its replication and attenuate the innate immune responses that it activates. In this review, we discuss the relationship between HCV and autophagy, and the crosstalk between HCV-induced autophagy and host innate immune responses.

【 授权许可】

Unknown