Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration

ESC Heart Failure

Jun Guo¹  Dongdong Chen¹  Ning Bian¹  Zhijie Liu¹  Yiming Fan¹ 

[1] Department of Cardiology The First Affiliated Hospital of Jinan University Guangzhou 510630 China;

关键词: Immune checkpoint inhibitors;    Myocarditis;    Arrhythmia;    Sacubitril/valsartan;    SGLT2i;   

DOI  :  10.1002/ehf2.13912

来源: DOAJ

【 摘 要 】

Abstract Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditis, the most dangerous one of irAEs, still has high mortality in the context of the current treatment. We report the case of a 60‐year‐old female with fulminant myocarditis induced by ICIs, which caused her to experience frequent ventricular arrhythmias such as ventricular fibrillation and heart failure. She was successfully treated with current mainstream therapies for immune‐related myocarditis and additional treatment of sacubitril–valsartan and dapagliflozin. The intriguing observation that the patient condition recovered relatively rapidly in this case shows a possible treatment inspiration, which may be helpful for treating ICIs‐associated myocarditis and improving cancer patients' clinical prognosis.

【 授权许可】

Unknown