Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

Frontiers in Cell and Developmental Biology

Guangwei Wang¹  Qian Liu¹  Mao Li¹  Zhousheng Xiao²  Yuanyuan Xiong³  Shiyi Wang⁵ 

[1] Biomedical Research Center, Hunan University of Medicine, Huaihua, China;Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States;Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China;Key Laboratory of Brain and Neuroendocrine Diseases, College of Hunan Province, Hunan University of Medicine, Huaihua, China;XiangYa School of Medicine, Central South University, Changsha, China;

关键词: osterix;    osteoblast differentiation;    therapy;    osteolytic diseases;    bone;   

DOI  :  10.3389/fcell.2020.601224

来源: DOAJ

【 摘 要 】

With increasing life expectations, more and more patients suffer from fractures either induced by intensive sports or other bone-related diseases. The balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the basis for maintaining bone health. Osterix (Osx) has long been known to be an essential transcription factor for the osteoblast differentiation and bone mineralization. Emerging evidence suggests that Osx not only plays an important role in intramembranous bone formation, but also affects endochondral ossification by participating in the terminal cartilage differentiation. Given its essentiality in skeletal development and bone formation, Osx has become a new research hotspot in recent years. In this review, we focus on the progress of Osx’s function and its regulation in osteoblast differentiation and bone mass. And the potential role of Osx in developing new therapeutic strategies for osteolytic diseases was discussed.

【 授权许可】

Unknown