Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective

Frontiers in Medical Technology

关键词: 3D in vitro models;    cell culture monolayers;    nanoparticles;    drug delivery;    drug targeting;    high-throughput screening;   

DOI  :  10.3389/fmedt.2022.909943

来源: DOAJ

【 摘 要 】

Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three-dimensional in vitro model in screening protocols. In this brief work, we discuss some of the issues that cancer nanomedicine will need to consider in the switch from bi-dimensional to three-dimensional multicellular tumor spheroid models.

【 授权许可】

Unknown