Light‐Activated Conjugated Polymers for Antibacterial Photodynamic and Photothermal Therapy

Advanced NanoBiomed Research

Anderson Rodrigues Lima Caires¹  Thais Fedatto Abelha¹ 

[1] Laboratory of Optics and Photonics Institute of Physics Federal University of Mato Grosso do Sul Campo Grande Mato Grosso do Sul 79070-900 Brazil;

关键词: antimicrobials;    bacteria;    conducting polymers;    photodynamic therapy;    phototherapy;    photothermal therapy;   

DOI  :  10.1002/anbr.202100012

来源: DOAJ

【 摘 要 】

With the growing crisis of the availability of effective antimicrobial treatments, the use of phototherapy has gained increasing interest as an alternative to traditional antibiotic therapy. Even though phototherapy is already used in the clinic, there is an emerging interest in new materials with enhanced antimicrobial activity triggered by light. Among the different light‐responsive materials, conjugated polymers are emerging candidates with successful application in the field of antimicrobial photodynamic and photothermal therapy. Due to their organic composition, easy processability, tailorability of physicochemical properties, and capability of reactive oxygen species (ROS) and heat generation, their use as photoresponsive agents against bacteria has greatly expanded. Conjugated polymers have been designed to interact with specific bacterial targets, and their chemical composition has been optimized to enhance ROS and/or heat generation and new cationic polymers have been developed for augmented water solubility and increased interaction with negatively charged bacteria. Herein, the use of conjugated polymers in the field of phototherapy is discussed, focusing on the different approaches that have improved their performance against bacteria and their current preclinical safety assessment.

【 授权许可】

Unknown