Dimensional connectomics of anxious misery, a human connectome study related to human disease: Overview of protocol and data quality

NeuroImage: Clinical

Yvette Sheline¹  Nicholas Balderston¹  Nathan Smyk¹  Darsol Seok¹  Marc Jaskir¹  Janet Stock¹  Walid Makhoul¹  Tommaso Girelli¹  J. Cobb Scott²  Ruben C. Gur²  Philip Cook³  Mark Elliott³  Christos Davatzikos³  Joanne Beer⁴  Russell Shinohara⁴ 

[1] Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States;Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States;Department of Radiology, Perelman School of Medicine, University of Pennsylvania, United States;Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, United States;

关键词: Anxious misery;    Human connectome project;    Brain imaging;    RDoC;    Depression;    Anxiety;   

DOI  :  

来源: DOAJ

【 摘 要 】

Disparate diagnostic categories from the Diagnostic and Statistical Manual of Mental Disorders (DSM), including generalized anxiety disorder, major depressive disorder and post-traumatic stress disorder, share common behavioral and phenomenological dysfunctions. While high levels of comorbidity and common features across these disorders suggest shared mechanisms, past research in psychopathology has largely proceeded based on the syndromal taxonomy established by the DSM rather than on a biologically-informed framework of neural, cognitive and behavioral dysfunctions. In line with the National Institute of Mental Health’s Research Domain Criteria (RDoC) framework, we present a Human Connectome Study Related to Human Disease that is intentionally designed to generate and test novel, biologically-motivated dimensions of psychopathology. The Dimensional Connectomics of Anxious Misery study is collecting neuroimaging, cognitive and behavioral data from a heterogeneous population of adults with varying degrees of depression, anxiety and trauma, as well as a set of healthy comparators (to date, n = 97 and n = 24, respectively). This sample constitutes a dataset uniquely situated to elucidate relationships between brain circuitry and dysfunctions of the Negative Valence construct of the RDoC framework. We present a comprehensive overview of the eligibility criteria, clinical procedures and neuroimaging methods of our project. After describing our protocol, we present group-level activation maps from task fMRI data and independent components maps from resting state data. Finally, using quantitative measures of neuroimaging data quality, we demonstrate excellent data quality relative to a subset of the Human Connectome Project of Young Adults (n = 97), as well as comparable profiles of cortical thickness from T1-weighted imaging and generalized fractional anisotropy from diffusion weighted imaging. This manuscript presents results from the first 121 participants of our full target 250 participant dataset, timed with the release of this data to the National Institute of Mental Health Data Archive in fall 2020, with the remaining half of the dataset to be released in 2021.

【 授权许可】

Unknown