Identification of potential key pathways, genes and circulating markers in the development of intracranial aneurysm based on weighted gene co-expression network analysis

Artificial Cells, Nanomedicine, and Biotechnology

Guojia Du¹  Dangmurenjiafu Geng¹  Qingjiu Zhou¹  Riqing Su¹  Yandong Fan¹  Serick Duysenbi¹  Kai Zhou¹  Bo Liu¹ 

[1] Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;

关键词: Intracranial aneurysm;    key pathways;    hub genes;    circulating markers;    ruptured intracranial aneurysm;    unruptured intracranial aneurysm;   

DOI  :  10.1080/21691401.2020.1770264

来源: DOAJ

【 摘 要 】

Background Intracranial aneurysm (IA) is a disease resulted from weak brain control, characterized by local expansion or dilation of brain artery. This study aimed to construct a gene co-expression network by Weighted Gene Correlation Network Analysis (WGCNA) to explore the potential key pathways and genes for the development of IA.Method Six IA-related gene expression data sets were downloaded from the Gene Expression Omnibus (GEO) database for identifying differentially expressed genes (DEGs). WGCNA was used to identify modules associated with IA. Functional enrichment analysis was used to explore the potential biological functions. ROC analysis was used to find markers for predicting IA.Results Purple, greenyellow and yellow modules were significantly associated with unruptured intracranial aneurysms, while blue and turquoise modules were significantly associated with ruptured intracranial aneurysms. Functional modules significantly related to IA were enriched in Ribosome, Glutathione metabolism, cAMP signalling pathway, Lysosome, Glycosaminoglycan degradation and other pathways. CD163, FCEREG, FPR1, ITGAM, NLRC4, PDG, and TYROBP were up-regulated ruptured intracranial aneurysms and serum, these genes were potential circulating markers for predicting IA rupture.Conclusions Potential IA-related key pathways, genes and circulating markers were identified for predicting IA rupture by WGCNA analysis.

【 授权许可】

Unknown